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Past projects

Dictyostelium discoideum

Dictyostelium discoideum is a microorganism that under normal conditions consists of independent single amoebas and under unfavourable conditions, these cells become “social” and enter a multicellular developmental program. After the initiation of starvation, pioneer cells release pulses of cyclic adenosine-3‘,5‘-monophosphate (cAMP). Nearby cells sense this compound and start to move chemotactically in the direction where the cAMP concentration rises most rapidly. By using chemotaxis, cells aggregate into multicellular object enabling them to survive unfavourable conditions.

Dictyostelium life cycle

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Pattern formation in Dictyostelium

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Temperature-sensitive PNIPAM microcapsules

 

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Biologicaly triggered release

A new method for triggering the burst liberation of encapsulated sub-micron particles from carrier particles using embedded microorganisms has been developed. Triggering mechanisms such as those based on chemical, light, thermal, or magnetic stimuli are known, but man-made particles are not yet able to replicate the concept of “dormancy” found in biological systems in the form of spores or seeds that survive in an inactive state and start to grow only once favourable environmental conditions are encountered. An engineered particle system that mimics this property by embedding viable yeast cells into synthetically made alginate microcapsules is reported in the present work. Cell growth and division is used as a triggering mechanism for stimuli-responsive release of the encapsulated content. The hybrid living/artificial capsules were formed by an inkjet printing process and the mechanism of biologically triggered release was shown using fluorescently labelled liposomes.

alginate (šířka 450px)

release (šířka 450px)

 

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Updated: 30.10.2021 10:42, Author: Jitka Čejková


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